Siponimod (Standard)
CAS No. : 1230487-00-9
(Synonyms: BAF-312 (Standard))
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| Cat. No. : | HY-12355R |
| M.Wt: | 516.60 |
| Formula: | C29H35F3N2O3 |
| Purity: | >98 % |
| Solubility: |
Siponimod (BAF-312) (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.
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