2-Aminoheptane

2-Aminoheptane (Tuaminoheptane) is a norepinephrine transporter inhibitor. 2-Aminoheptane binds to norepinephrine transporter via ionic and hydrophobic interactions to block norepinephrine uptake. 2-Aminoheptane deactivates ω-TAmla enzyme, reduces recombinant whole cell stability, and acts as an amino group donor substrate for ω-TA and ω-TAmla enzymes. 2-Aminoheptane can be used in research on depression and Alzheimer's disease^[1][2][3][4]. In Vitro: 2-Aminoheptane inhibits [3H]norepinephrine uptake in HEK cells, with an IC₅₀ of 3.7 μM^[1].
2-Aminoheptane (0-250 mM; 1 h) shows that crude cell extracts of ω-TAmla-expressing E. coli BL21 are completely deactivated by 80 mM (without PLP) at 37°C for 1 h, while whole cells retain 44.4% activity at 150 mM 2-aminoheptane with 1 mM PLP^[3].
2-Aminoheptane (2 mM) serves as the sole nitrogen source and successfully enriches E. coli BL21 expressing ω-TA mutants with reduced product inhibition, leading to the isolation of ω-TAmla^[3].
2-Aminoheptane combined with NAC (HY-B0215) quickly relieves nasal congestion, significantly reduce resistance and increase inspiratory flow rate^[4].