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D-erythro-Sphingosine


CAS No. : 123-78-4

(Synonyms: Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine)

123-78-4
Price and Availability of CAS No. : 123-78-4
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5mg $32 In-stock
10mg $50 In-stock
25mg $80 In-stock
50mg $140 In-stock
100mg $210 In-stock
500mg $525 In-stock
1g $840 In-stock
5g $2100 In-stock
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Cat. No. : HY-101047
M.Wt: 299.49
Formula: C18H37NO2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 123-78-4 :

D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4]. IC50 & Target: EC50: 8 μM (p32-kinase)[1]
PKC[2][3] In Vitro: A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3].

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