Diethyl succinate
CAS No. : 123-25-1
(Synonyms: Diethyl Butanedioate)
| Size | Price | Stock |
|---|---|---|
| 500g | $28 | In-stock |
| 1000g | $53 | In-stock |
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| Cat. No. : | HY-Y0836 |
| M.Wt: | 174.19 |
| Formula: | C8H14O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 250 mg/mL |
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings[1][2]. In Vitro: Diethyl succinate (5 mM; 3 h) reduces ROS production in primary microglia[2]. Diethyl succinate (0-10 mM; 0.25-3 h) induces decreased mitochondrial fission in primary microglia[2].
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