HA130
CAS No. : 1229652-21-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $205 | In-stock |
| 50mg | $330 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-19329 |
| M.Wt: | 463.29 |
| Formula: | C24H19BFNO5S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 39 mg/mL |
HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.
In Vitro: HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1].
In Vivo: HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].
The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].
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