Modipafant
CAS No. : 122957-06-6
(Synonyms: UK-80067)
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| Cat. No. : | HY-108908A |
| M.Wt: | 605.09 |
| Formula: | C34H29ClN6O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505[1][2]. In Vitro: when preincubated with rabbit platelets, the potency of antagonizing PAF induced aggregation increased markedly when preincubation time with Modipafant was increased from 2 min (IC50=5.6 nM) to 60 min (IC50=0.34 nM)[2].
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