Doxepin (Hydrochloride)
CAS No. : 1229-29-4
| Size | Price | Stock |
|---|---|---|
| 500mg | $35 | In-stock |
| 1g | $50 | In-stock |
| 5g | $110 | In-stock |
| 10g | $160 | In-stock |
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| Cat. No. : | HY-B0725 |
| M.Wt: | 315.84 |
| Formula: | C19H22ClNO |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL;DMSO : ≥ 100 mg/mL |
Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2]. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant[3].. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system[4].. Doxepin has also been proposed as a protective factor against oxidative stress[5].. In Vitro: The protective effect of doxepin is associated with the enhancement of PSD-95 and synapsin 1 expression via PI3K/AKT/mTOR signaling pathway[6].. In Vivo: Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days) can protect against the Aβ1-42-induced memory impairment in rats[6]..
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