Itopride
CAS No. : 122898-67-3
(Synonyms: HSR803 (free base))
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| Cat. No. : | HY-B0732A |
| M.Wt: | 358.43 |
| Formula: | C20H26N2O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1].
IC50 & Target: Dopamine-2, AChE[1]
In Vitro: Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3].
Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3].
In Vivo: Itopride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group[4].
Itopride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min[4].
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