Pacritinib (hydrochloride)
CAS No. : 1228923-43-0
(Synonyms: SB1518 (hydrochloride))
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| Cat. No. : | HY-16379A |
| M.Wt: | 1000.00 |
| Formula: | C28H32N4O3.xClH |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pacritinib hydrochloride is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib hydrochloride also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)[1][2][3]. IC50 & Target:IC50: 6 nM (FLT3D835Y), 22 nM (FLT3wt), 19 nM (JAK2V617F), 23 nM (JAK2wt)[1]
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