Itopride (hydrochloride)
CAS No. : 122892-31-3
(Synonyms: HSR803)
| Size | Price | Stock |
|---|---|---|
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| 500mg | $90 | In-stock |
| 1g | $137 | In-stock |
| 5g | $439 | In-stock |
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| Cat. No. : | HY-B0732 |
| M.Wt: | 394.89 |
| Formula: | C20H27ClN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1][2].
IC50 & Target: AChE, D2DR[1]
In Vitro: Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3].
Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3].
In Vivo: Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group[4].
Itopride hydrochloride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min[4].
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