Alosetron (Hydrochloride)
CAS No. : 122852-69-1
(Synonyms: GR 68755C; GR 68755 (Hydrochloride); GR 68755X (Hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 10mg | $40 | In-stock |
| 25mg | $88 | In-stock |
| 50mg | $141 | In-stock |
| 100mg | $227 | In-stock |
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| Cat. No. : | HY-70050C |
| M.Wt: | 330.81 |
| Formula: | C17H19ClN4O |
| Purity: | >98 % |
| Solubility: | H2O : 33.33 mg/mL (ultrasonic) |
Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2]. In Vivo: Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis[2].
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