Sabutoclax
CAS No. : 1228108-65-3
(Synonyms: BI-97C1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $549 | In-stock |
| 10mg | $995 | In-stock |
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| Cat. No. : | HY-15191 |
| M.Wt: | 700.78 |
| Formula: | C42H40N2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 36.67 mg/mL (ultrasonic) |
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively. Sabutoclax increases Bax, Bim, PUMA and survivin expression[1][2].
IC50 & Target:IC50: 0.32 μM (Bcl-2), 0.31 μM (Bcl-XL), 0.20 μM (Mcl-1), and 0.62 μM (Bfl-1) [1].
In Vitro: Sabutoclax (0.001-10 μM; 72 h) potentially inhibits cell growth of human prostate cancer, lung cancer cell line[1].
Sabutoclax (0.01 μM-1 μM; 24-48 h) potentially induces cell apoptosis in human diffuse large B-cell lymphoma cell line[1].
Sabutoclax (0 μM-15 μM; 48 h) uptrgulates the level of pro-apoptotic proteins in chemoresistent cells[2].
In Vivo: Sabutoclax (1-5 mg/kg; i.p.; every two days in 18 D) reduces tumor growth in M2182-bearing athymic nude mice[1].
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