PAR-4 Agonist Peptide, amide (TFA)
CAS No. : 1228078-65-6
(Synonyms: PAR-4-AP (TFA); AY-NH2 (TFA))
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|---|---|---|
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| 5mg | $180 | In-stock |
| 10mg | $300 | In-stock |
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| Cat. No. : | HY-P1309A |
| M.Wt: | 794.82 |
| Formula: | C36H49F3N8O9 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 250 mg/mL;H2O : 100 mg/mL (ultrasonic) |
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1]. IC50 & Target:PAR-4[1] In Vivo:Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].
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