BI-4464
CAS No. : 1227948-02-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $432 | In-stock |
| 50mg | $648 | In-stock |
| 100mg | $907 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124625 |
| M.Wt: | 555.55 |
| Formula: | C28H28F3N5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC50 value of 17 nM. BI-4464 is a FAK (HY-43760) ligand and linker conjugate. BI-4464 can be used to construct proteolysis targeting chimeras (PROTACs), such as PROTAC FAK degrader 4 (HY-178467). PROTAC FAK degrader 4 is a highly potent and selective FAK PROTAC degrader[1][2][3]. IC50 & Target:IC50: 17 nM (PTK2/FAK)[1]. In Vitro:BI-4464 (0-10 μM, 18 h) inhibits human liver cancer cell proliferation by targeted degradation of PTK2 protein, with a pIC50 value of 5[1]. BI-4464 (0-20 μM, 48 h) has anti-Ebola potential by inhibiting aberrant endothelial cell (EC) activation through the inhibition of TNF-α and EBOV-like particles (VLP) -mediated up-regulation of ICAM-1[2].
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