MK-7622
CAS No. : 1227923-29-6
(Synonyms: M1 receptor modulator)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $240 | In-stock |
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| Cat. No. : | HY-15618 |
| M.Wt: | 399.48 |
| Formula: | C25H25N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 70 mg/mL (ultrasonic) |
MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs). MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine (HY-N0296)-induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD)[1][2].
IC50 & Target:M1 receptor[1]
In Vitro:MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM)[1].
MK-7622 shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium (EC50 = 2930 nM without ACh; PAM EC50 = 16 nM with ACh)[2].
In Vivo:MK-7622 (0.1-1.0 mg/kg, p.o., once, 5 h before testing) significantly attenuates Scopolamine (HY-N0296)-induced impairment in performance of difficult trials in object retrieval detour task of rhesus monkeys[1].
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