Stemregenin 1
CAS No. : 1227633-49-9
(Synonyms: SR1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $41 | In-stock |
| 10mg | $66 | In-stock |
| 50mg | $211 | In-stock |
| 100mg | $370 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15001 |
| M.Wt: | 429.54 |
| Formula: | C24H23N5OS |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM. IC50 & Target:IC50: 127 nM (AhR)[1] In Vitro:Stemregenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). Stemregenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. Stemregenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that Stemregenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR[1]. An aryl hydrocarbon receptor antagonist, Stemregenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. Stemregenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX[2].
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