Deltorphin I
CAS No. : 122752-15-2
(Synonyms: Deltorphin 1; Deltorphin C; [D-Ala2] Deltorphin I)
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| 10mg | $270 | In-stock |
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| Cat. No. : | HY-P1336 |
| M.Wt: | 768.86 |
| Formula: | C37H52N8O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity. IC50 & Target:δ-opioid receptor[1] In Vivo: Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05, <0.05 and <0.05), and this effect is dose dependent[1].
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