Ibutilide (fumarate)
CAS No. : 122647-32-9
(Synonyms: U70226E)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $72 | In-stock |
| 50mg | $120 | In-stock |
| 100mg | $216 | In-stock |
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| Cat. No. : | HY-B0387 |
| M.Wt: | 442.61 |
| Formula: | C22H38N2O5S |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : ≥ 50 mg/mL |
Ibutilide (U70226E) fumarate, an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells[1].
In Vitro: Ibutilide fumarate is a potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells[1].
Ibutilide fumarate blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5 nM vs 27.4 nM). However, cells expressing MDR1*7 show a marked resistance to Ibutilide (IC50: 105.3 nM vs 27.4 nM)[2].
In Vivo: Ibutilide fumarate prolongs cardiac repolarization in vitro and in vivo[1].
Ibutilide (administered cumulatively in three doses, 0.01, 0.02 and 0.05 mg/kg i.v., each as a 10-min infusion) fumarate results in both polymorphic and monomorphic non-sustained ventricular tachycardia[3].
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