Tyrphostin AG213
CAS No. : 122520-86-9
(Synonyms: AG213)
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| Cat. No. : | HY-101959 |
| M.Wt: | 220.25 |
| Formula: | C10H8N2O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].
In Vitro:Tyrphostin AG213 (25 μM, 50 μM, and 75 μM; 24 h, 48 h, and 96 h) increases wound closure time in human umbilical vein endothelial cell (HUVEC) monolayer[1].
Tyrphostin AG213 (100 μM; 1 h) interferes with HUVEC focal adhesion and stress fiber formation[1].
Tyrphostin AG213 (100 μM; 24 h) inhibits adherence-related tyrosine phosphorylation of pp125FAK in HUVEC[1].
Tyrphostin AG213 (10 μM; 24 h) inhibits tyrosine kinase activity, and (4.55-455 mM; 24-72 h) inhibits HT-29 cell viability dose- and time-dependently[2].
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