BIIB021 (mesylate)
CAS No. : 1225041-97-3
(Synonyms: CNF2024 (mesylate))
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| Cat. No. : | HY-10212A |
| M.Wt: | 414.87 |
| Formula: | C15H19ClN6O4S |
| Purity: | >98 % |
| Solubility: |
BIIB021 (CNF2024) mesylate is the mesylate of BIIB021 (HY-10212). BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML[1].
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