MK-3697
CAS No. : 1224846-01-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $150 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12301 |
| M.Wt: | 447.51 |
| Formula: | C23H21N5O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 22.5 mg/mL (ultrasonic;warming) |
MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. IC50 value: 0.95 nM(Ki) Target: Orexin 2 receptor antagonist MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development. Herein we report additional SAR studies within the “triaryl” amide 2-SORA series focused on improvements in compound stability in acidic media and time-dependent inhibition of CYP3A4. MK-3697 has improved stability and TDI profiles as well as excellent sleep efficacy across species.
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