4'-Bromo-resveratrol
CAS No. : 1224713-90-9
(Synonyms: 4′‐BR)
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|---|---|---|
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| 250mg | $90 | In-stock |
| 1g | $230 | In-stock |
| 5g | $839 | In-stock |
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| Cat. No. : | HY-124113 |
| M.Wt: | 291.14 |
| Formula: | C14H11BrO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
4'-Bromo-resveratrol (4′‐BR) is a dual SIRT1/SIRT3 inhibitor with an IC50 of 0.2 mM for both targets. 4'-Bromo-resveratrol induces caspase-dependent apoptosis, induces G0/G1 cell cycle arrest, and inhiibits proliferation. 4'-Bromo-resveratrol reduces lactate production, glucose uptake, and NAD+/NADH ratio, and downregulates lactate dehydrogenase A and glucose transporter 1 (GLUT1). 4'-Bromo-resveratrol can be used for the research of melanoma[1].
In Vitro:4'-Bromo-resveratrol (0.0125-0.2 mM; 24-72 h) dose- and time-dependently inhibits proliferation and viability of G361, SK-MEL-28, and SK-MEL-2 human melanoma cells[1].
4'-Bromo-resveratrol (0.0125-0.2 mM; 48 h) dose-dependently impairs clonogenic survival of G361, SK-MEL-28, and SK-MEL-2 human melanoma cells[1].
4'-Bromo-resveratrol (0.0125-0.05 mM; 24-72 h) dose- and time-dependently induces apoptosis in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells, inducing apoptotic morphological changes, including nuclear condensation and fragmentation[1].
4'-Bromo-resveratrol (0.05 mM; 48 h) mediates G0/G1 phase arrest in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells via P21-induced inhibition of Cyclin D1 and CDK6 after 48 hours of treatment[1].
4'-Bromo-resveratrol (0.05 mM; 48 h) reduces expression of glycolysis-related proteins LDHA and GLUT1 in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells after 48 hours of treatment[1].
4'-Bromo-resveratrol (0.05 mM; 48 h) significantly inhibits migration of G361, SK-MEL-28, and SK-MEL-2 human melanoma cells[1].
4'-Bromo-resveratrol (0.025-0.05 mM; 48 h) dose-dependently inhibits aerobic glycolysis in G361, SK-MEL-28, and SK-MEL-2 human melanoma cells, reducing lactate production, glucose uptake, and NAD+/NADH ratio[1].
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