Temoporfin
CAS No. : 122341-38-2
(Synonyms: m-THPC; KW2345)
| Size | Price | Stock |
|---|---|---|
| 5mg | $132 | In-stock |
| 10mg | $228 | In-stock |
| 25mg | $468 | In-stock |
| 50mg | $828 | In-stock |
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| Cat. No. : | HY-16488 |
| M.Wt: | 680.75 |
| Formula: | C44H32N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C) |
Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers[1][2][3]. In Vitro:A detailed confocal fluorescence microscopy study of a human adenocarcinoma shows weak localization of Temoporfin in lysosomes and mitochondria. Instead, it is found to be localized in the endoplasmic reticulum (ER) and the Golgi apparatus[1]. In Vivo:Temoporfin in liver tissue decreases rapidly in time after initial high levels at 4 h after administration (0.1-0.3 mg/kg). In tumour tissue no decrease in photosensitizer levels occurred, with Temoporfin remaining high up to 48 h after administration[2].
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