ML169
CAS No. : 1222878-02-5
(Synonyms: VU0405652)
| Size | Price | Stock |
|---|---|---|
| 5mg | $234 | Get quote |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-120576 |
| M.Wt: | 506.34 |
| Formula: | C21H17BrFN3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1].
IC50 & Target: EC50: 1.38 µM (M1 mAChR)[1]
In Vitro: ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M1–M5[1].
ML169 shifts APP processing towards a non-amyloidogenic pathway[1].
ML169 (2 µM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 µM CCh[1].
In Vivo: ML169 (VU0405652) (10 mg/kg; i.p.) affords a brainAUC/plasmaAUC of 0.32 at 1 h in rats[1].
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