ML133 (hydrochloride)
CAS No. : 1222781-70-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $77 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $231 | In-stock |
| 100mg | $385 | In-stock |
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| Cat. No. : | HY-100230A |
| M.Wt: | 313.82 |
| Formula: | C19H20ClNO |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 0.1 mg/mL;DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].
IC50 & Target: IC50: 1.8 μM (Kir2 at pH 7.4), 290 nM (Kir2 at pH 8.5)[1].
In Vitro: ML133, which inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5, but exhibits little selectivity against other members of Kir2.x family channels[1].
ML133 has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date[1].
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