DS-7423
CAS No. : 1222104-37-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $360 | In-stock |
| 10mg | $550 | In-stock |
| 25mg | $900 | In-stock |
| 50mg | $1260 | In-stock |
| 100mg | $1760 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124036 |
| M.Wt: | 520.51 |
| Formula: | C22H27F3N10O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].
In Vitro: DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1].
DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM)[2].
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