Evogliptin
CAS No. : 1222102-29-5
(Synonyms: DA-1229)
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| Cat. No. : | HY-117985 |
| M.Wt: | 401.42 |
| Formula: | C19H26F3N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation[1][2][3][4].
IC50 & Target:DPP4[1][2][3][4].
In Vitro: Evogliptin (2.49 mM; 12 h) efficiently inhibits mDPP4 (membrane DPP4) enzymatic activity in PWM-induced H9 Th1 cells[1].
Evogliptin prevents inflammatory and fibrotic signaling through autophagy induction in primary hepatocytes of ATG7f/f-Cre+ mice[2].
In Vivo: Evogliptin (100, 300 mg/kg; in animal feedings; single daily for 10 weeks) exhibits antidiabetic effects on HFD/STZ mice and improves glucose intolerance and insulin resistance[3].
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