AM-5262
CAS No. : 1222088-90-5
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| Cat. No. : | HY-16619 |
| M.Wt: | 514.63 |
| Formula: | C33H35FO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AM-5262 is a GPR40 full agonist with an EC50 value of 0.081 μM. AM-5262 can be used for the research of type II diabetes[1].
IC50 & Target:EC50: 0.081 μM (GPR40)[1]
In Vitro: AM-5262 has activity for GPR40 with an EC50 value of 0.081 μM[1].
In Vivo: AM-5262 (26) (i.v., 0.5 mg/kg; oral, 2 mg/kg) improves rat PK profile and general selectivity profile[1].
AM-5262 (0-100 μM) enhances glucose stimulated insulin secretion (mouse and human islets) and improves glucose homeostasis in vivo (OGTT in HF/STZ mice) [1].
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