Gymnemic acid I
CAS No. : 122168-40-5
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| 5mg | $250 | In-stock |
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| Cat. No. : | HY-N2541 |
| M.Wt: | 806.98 |
| Formula: | C43H66O14 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR[1][2].
In Vitro:In ribosomes from rabbit reticulocytes, Gymnemic acid I (1, 10, and 100 μM) decreases the luciferase translation in a concentration-dependent manner[1].
Gymnemic acid I (5 μg/mL; 36 hr) decreases the apoptosis under the high glucose stress[2].
Gymnemic acid I (5 μg/mL; 36 hr) increases the number of autophagosome and the ratio of light chain 3-I (LC3-I)/LC3-II in MIN-6 cells under the normal or high glucose stress. Gymnemic acid I induces autophagy flux and inhibited the phosphorylation of mTOR and ribosomal protein S6 kinase β-1 (p70 S6K/S6K1), which is a substrate of mTOR. Gymnemic acid I decreases the rate of apoptosis and the activity of caspase-3 under the high glucose stress[2].
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