TC-I 2014
CAS No. : 1221349-53-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $520 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1380 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110199 |
| M.Wt: | 467.41 |
| Formula: | C23H19F6N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1]. IC50 & Target: TRPM8[1]. In Vitro: TC-I 2014 (compound 5) potently inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8, with IC50 values of 0.413 and 1 nM, respectively[1]. In Vivo: TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS[1].
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