Zingerone
CAS No. : 122-48-5
(Synonyms: Vanillylacetone; Gingerone)
| Size | Price | Stock |
|---|---|---|
| 5g | $24 | In-stock |
| 25g | $62 | In-stock |
| 100g | $143 | In-stock |
| 500g | $509 | In-stock |
| 1 kg | Get quote | |
| 2 kg | Get quote | |
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| Cat. No. : | HY-14621 |
| M.Wt: | 194.23 |
| Formula: | C11H14O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3]. Zingerone can cross the blood-brain barrier (BBB)[4].
IC50 & Target:NF-κB[3]
In Vitro:Zingerone is a nontoxic methoxyphenol with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic properties[1].
Zingerone (0-2 mM) decreases neruoblastoma cell survival[3].
Zingerone (0-2 mM) reduces cyclin D1 expression, increases cleavage of caspase-3 and PARP-1 in BE(2)-M17 cells[3].
In Vivo:Zingerone (50, 100 mg/kg, p.o. daily for 21 days) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation in rat[2].
Zingerone (10 mg/kg, i.p.) inhibits tumor progression through mitotic arrest, failure of cell division, and stimulation of apoptosis[3].
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