Stilbamidine

Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections. IC50 & Target: fungal In Vitro: The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine. [³H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC₅₀=1.2 μM) or melarsen oxide (IC₅₀=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC₅₀=6.1 μM) and Stilbamidine (IC₅₀=110 μM)^[1]. The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence^[2].