Cuminaldehyde

Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL), α-glucosidase (IC₅₀=0.5 mg/mL) and lipoxygenase (IC₅₀=1370 μM). Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases^{[1][2][3][4][5][6][7]}. In Vitro:Cuminaldehyde (1 mM; 24-96 h) can effectively inhibit α-synuclein (α-SN) fibrillation. The presence of α-SN fibrillation inducer Spermidine (HY-B1776) enhances the inhibitory effect, which is even stronger than the inhibitory effect of Baicalein (HY-N0196)^[1].
Cuminaldehyde (0-160 μM; 12-48 h) inhibits the proliferation of human colon COLO 205 cells and induces cell apoptosis^[2].
Cuminaldehyde (0.5 and 1.5 μM; 5 d) inhibits the growth of Aspergillus flavus (IC₅₀=0.25 μL/mL) and induces necrosis of Aspergillus flavus^[5].
Cuminaldehyde (0-0.8 μL/mL; 5 d) inhibits the synthesis of aflatoxin (AFB1), a secondary metabolite of Aspergillus flavus^[5].
In Vivo:Cuminaldehyde (5-20 mg/kg; intratumoral injection; once a day for 42 days) inhibits tumor growth in mice bearing human colorectal cancer COLO 205 xenografts^[2].
Cuminaldehyde (50-200 mg/kg; i.g.; single dose injection 30 minutes before hot plate test) significantly reduces the latency of nociceptive response in rats in hot plate test^[6].
Cuminaldehyde (12.5-50 mg/kg; i.p.; single dose injection 30 minutes before the test) significantly inhibits pain perception in mice with abdominal pain induced by Acetic acid (HY-Y0319) and formalin^[6].
Cuminaldehyde (25-100 mg/kg; i.p.; once daily for 14 days) significantly alleviates allodynia and hyperalgesia in rats with chronic constriction injury (CCI) model^[6].