(±)-Anatoxin A (fumarate)
CAS No. : 1219922-30-1
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| Cat. No. : | HY-N2326 |
| M.Wt: | 281.30 |
| Formula: | C14H19NO5 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 14.07mg/mL;10 mM in DMSO |
(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to α4β2- and α7-type nicotinic receptors in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM). (±)-Anatoxin A fumarate has toxic effect on fish[1][2][3][4]. IC50 & Target:Ki: 1.25 nM ( α4β2 receptor)Ki: 1.84 μM ( α7 receptor)[1] In Vitro:(±)-Anatoxin A fumarate (50-200 μg/mL, 24 h) reduces the viability of Jurcat and THP-1 cells[2]. In Vivo:Exposure with (±)-Anatoxin A fumarate (0.08-0.31 μg/g, i.p.), fish may experience motor difficulties, possibly becoming vulnerable to predators, and be at increased metabolic demand[4].
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