RSL3


CAS No. : 1219810-16-8

(Synonyms: (1S,3R)-RSL3)

1219810-16-8
Price and Availability of CAS No. : 1219810-16-8
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2mg $60 In-stock
5mg $90 In-stock
10mg $160 In-stock
25mg $330 In-stock
50mg $560 In-stock
100mg $990 In-stock
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Cat. No. : HY-100218A
M.Wt: 440.88
Formula: C23H21ClN2O5
Purity: >98 %
Solubility: DMSO : 100 mg/mL (226.82 mM; Need ultrasonic)
Introduction of 1219810-16-8 :

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1]. IC50 & Target: Glutathione peroxidase 4[1] In Vitro: RSL3 (0-8 μM, 72 hours) potently reduces the viability of HN3 cells, with IC50s of 0.48 µM in HN3 and 5.8 µM in HN3-rslR cells, respectively[1].
RSL3 (0-8 μM, 24 hours) reduces the expression of GPX4 protein, increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1]. In Vivo: RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with trigonelline in mice bearing HN3R cells.

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