4-Iodo-SAHA
CAS No. : 1219807-87-0
(Synonyms: ISAHA)
| Size | Price | Stock |
|---|---|---|
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| 200 mg | Get quote | |
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| Cat. No. : | HY-124007 |
| M.Wt: | 390.22 |
| Formula: | C14H19IN2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC50s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer[1]. In Vitro:4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines [1]. 4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells[1]. In Vivo:4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity[1].
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- 4-Iodo-SAHA
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- HY-124007
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