(-)-Dizocilpine (maleate)
CAS No. : 121917-57-5
(Synonyms: (-)-MK-801 (maleate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $280 | In-stock |
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| Cat. No. : | HY-15084A |
| M.Wt: | 337.37 |
| Formula: | C20H19NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);Ethanol : 25 mg/mL (ultrasonic);H2O : 8.33 mg/mL (ultrasonic;warming;heat to 60°C) |
(-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects[1][2]. IC50 & Target: Ki: 211.7 nM (N-methyl-D-aspartate (NMDA) receptor)[1] In Vitro: (-)-Dizocilpine maleate ((-)-MK-801 maleate) significantly inhibited the uptake of all three (norepinephrine, dopamine and serotonin) monoamine transporters in a dose-dependent manner in HEK cells. The Ki values of (-)-Dizocilpine on the norepinephrine, dopamine and serotonin transporters are 3.7 μM, 40 μM and 47 μM, respectively[2]. In Vivo: (-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model[1].
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