Xylometazoline (hydrochloride)
CAS No. : 1218-35-5
| Size | Price | Stock |
|---|---|---|
| 25g | $98 | In-stock |
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| Cat. No. : | HY-B0475 |
| M.Wt: | 280.84 |
| Formula: | C16H25ClN2 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic) |
Xylometazoline hydrochloride is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2][3][4].
In Vitro:Xylometazoline hydrochloride has affinity for α1A-adrenoceptor and α2B-adrenoceptor in HEK293 cells[2].
In Vivo:Xylometazoline (1 mg/mL, intranasal, single dose) hydrochloride improves sinusitis in rats[3].
Xylometazoline hydrochloride and its excipients, when used for prolonged periods, may cause ophthalmic problems such as dry eyes, corneal edema, cataracts, retinal nerve fiber layer damage, and vascular damage[4].
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