| Size | Price | Stock |
|---|---|---|
| 5mg | $600 | In-stock |
| 10mg | $960 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-101317 |
| M.Wt: | 506.27 |
| Formula: | C23H26Br2N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke[1][2].
In Vitro:TAN-67 (SB-205607) dihydrobromide has high potency (EC50=1.72 nM) for the inhibition of forskolin-stimulated cAMP accumulation at human delta-opioid receptors expressed by intact Chinese hamster ovary cells but low potency (EC50=1520 nM) at human mu-opioid receptors expressed by intact B82 mouse fibroblast cells[1].
In Vivo:TAN-67 (SB-205607; 1.5-4.5 mg/kg; i.v.; once) dihydrobromide reduces infarct volume in I/R-caused brain injury[2].
TAN-67 (3 mg/kg; i.v.; once) dihydrobromide improves survival and neurobehavioral performance after I/R[2].
TAN-67 (3 mg/kg; i.v.; once; adult C57BL/6J male mice) dihydrobromide increases both total APP and mature APP (APPm) levels and APP processing at an early time point (6 h)[2].
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