PTC-209 (hydrobromide)
CAS No. : 1217022-63-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $154 | In-stock |
| 25mg | $339 | In-stock |
| 50mg | $594 | In-stock |
| 100mg | $979 | In-stock |
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| Cat. No. : | HY-15888A |
| M.Wt: | 576.10 |
| Formula: | C17H14Br3N5OS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2].
IC50 & Target: IC50: 0.5 μM (BMI-1, in HT1080 tumor cells)[1]
In Vitro: PTC-209 (0.01-10 µM; 24-72 hours) induces a concentration- and time-dependent decrease in the cellular viability of all cell lines tested[2].
PTC-209 (1-2.5 μM) inhibits STAT3 phosphorylation in A549 lung cancer cells and MDA-MB-231 breast cancer cells[2].
In Vivo: PTC-209 (60 mg/kg body weight; subcutaneously; once a day for 11 days) significantly reduces tumor volume[2].
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