GSK4112
CAS No. : 1216744-19-2
(Synonyms: SR6452)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $198 | In-stock |
| 50mg | $316 | In-stock |
| 100mg | $510 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-14414 |
| M.Wt: | 396.89 |
| Formula: | C18H21ClN2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways[1]. In Vitro: GSK4112 (0-100 μM; 1 h) interacts with Rev-erbα with an EC50 value of 0.4 μM[1]. GSK4112 (10 μM; 6 h) represses expression of bmal1 and the target genes associated with the pathway of gluconeogenesis, recruits HDAC3 and modulates the effect of Rev-erbα on oscillation of hepatic gene expression[1]. GSK4112 (10 μM; 16 h) reduces glucose output in murine hepatocytes[1]. In Vivo: GSK4112 (25 mg/kg; i.p. 0.5 h before Jo2 exposure) attenuates Fas-induced hepatic damage[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- GSK4112
- Cat. No.:
- HY-14414
- Quantity:
Your information is safe with us.