YM-298198 (hydrochloride)
CAS No. : 1216398-09-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $420 | In-stock |
| 50mg | $720 | In-stock |
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| Cat. No. : | HY-103568 |
| M.Wt: | 378.92 |
| Formula: | C18H23ClN4OS |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C) |
YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders[1].
In Vitro: YM-298198 hydrochloride shows a high affinity for mGluR1 with a Ki of 19 nM for rat mGluR1-NIH membranes[1].
YM-298198 hydrochloride inhibits glutamate-induced inositol phosphate production in mGluR1-NIH3T3 cells, with an IC50 of 16 nM[1].
YM-298198 hydrochloride shows neither agonistic nor antagonistic activity on mGluR2, 3, 4a, 6, or 7b up to 10 μM[1].
In Vivo: YM-298198 hydrochloride (30 mg/kg; p.o.) shows a significant analgesic effect in streptozotocin-induced hyperalgesic mice[1].
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