FSC231
CAS No. : 1215849-96-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $225 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117772 |
| M.Wt: | 313.14 |
| Formula: | C13H10Cl2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects[1].
IC50 & Target:PICK1[1].
In Vitro:FSC231 (50 μM) blocks binding between GluR2 and PICK1 in COS7 cells[2].
In Vivo:FSC231 (78.40 μg/kg in total, daily, seven times, i.p., 3 h before Paclitaxel) alleviates the Paclitaxel (HY-B0015)‐induced neuralgia of rats[1].
FSC231 (39.2μg/kg/day, i.p., for 4 weeks) inhibits the development of diabetic cardiomyopathy in rats by inhibiting ROS generation and apoptosis partly via PICK1/eNOS/cGMP pathway[3].
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