UCN-02
CAS No. : 121569-61-7
(Synonyms: 7-epi-Hydroxystaurosporine)
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| Cat. No. : | HY-108262 |
| M.Wt: | 482.53 |
| Formula: | C28H26N4O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC50 value of 62 nM and a PKA IC50 value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma[1][2][3][4].
IC50 & Target:IC50: 62 nM (PKC), 250 nM (PKA)[2]
In Vitro:UCN-02 (0.25-0.37 μg/mL; 48-72 h) is produced by Streptomyces strain N-126[1].
UCN-02 inhibits purified protein kinase C (PKC) with an IC50 of 0.062 μM[2].
UCN-02 inhibits purified protein kinase A (PKA) with an IC50 of 0.25 μM[2].
UCN-02 (72 h) inhibits the growth of HeLa S3 cells[2].
UCN-02 (5-6 days) inhibits the growth of human breast carcinoma cell lines MDA-MB468 (IC50 = 100 nM), H85787 (IC50 = 20 nM), SK-BR-3 (IC50 = 200 nM), MDA-MB453 (IC50 = 350 nM), and MCF-7 (IC50 = 150 nM)[3].
UCN-02 (24 h-6 days) causes exposure-dependent growth inhibition in MDA-MB468 and MCF-7 human breast carcinoma cells[3].
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