TCV-309 (chloride)
CAS No. : 121494-09-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $440 | In-stock |
| 25mg | $880 | In-stock |
| 50mg | $1400 | In-stock |
| 100mg | $2100 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19121A |
| M.Wt: | 629.97 |
| Formula: | C30H34BrClN4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 6.3 mg/mL (ultrasonic) |
TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC50 values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock[1][2].
In Vivo: In rats, TCV-309 selectively inhibits the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 most potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively[1].
TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively[1].
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