WZ4003
CAS No. : 1214265-58-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $88 | In-stock |
| 50mg | $220 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-15802 |
| M.Wt: | 496.99 |
| Formula: | C25H29ClN6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases. IC50 & Target: IC50: 20 nM (NUAK1), 100 nM (NUAK2) In Vitro: WZ4003 (3-10 μM) markedly suppresses NUAK1-mediated MYPT1 phosphorylation, in HEK-293 cells expressing wild-type NUAK1. Moreover, WZ4003 (10 μM) inhibits MYPT1 Ser445 phosphorylation as well as cell migration, invasion and proliferation to a similar extent as knock out in MEFs or knock down in U2OS cells of NUAK1[1]. WZ4003 also exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50 against T790M containing Ba/F3 cells[2].
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