Sodium metatungstate
CAS No. : 12141-67-2
(Synonyms: Sodium polyoxotungstate; POM-1)
| Size | Price | Stock |
|---|---|---|
| 10mg | $28 | In-stock |
| 25mg | $55 | In-stock |
| 50mg | $77 | In-stock |
| 100mg | $108 | In-stock |
| 500mg | $270 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-103259 |
| M.Wt: | 2986.01 |
| Formula: | H2Na6O40W12 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission[1][2][3][4].
IC50 & Target:Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].
In Vitro:Sodium metatungstate (100 μM, 15 min) inhibits the ATP-induced uptake of anionic dyes and the large ATP-induced channels in macrophage[2].
Sodium metatungstate (100 μM, 8 h) inhibits ATP-induced P2X7-associated pyroptosis in macrophage[2].
Sodium metatungstate (100 μM, 8-24 h) has a potent anti-inflammatory effect on macrophages[2].
In Vivo:Sodium metatungstate (5 mg/kg, Intraperitoneal injection, single dose) shows different cytokine/chemokine responses in the peritoneum and systemically in the bloodstream in CD39 knockout mice[3].
Sodium metatungstate (5 mg/kg, Intraperitoneal injection, once per day from 0 to day 4, day 7-11, and day 14-18.) combine with anti-CD73 antibody and AZD4635(HY-101980) reduces tumor load in multiple myeloma (MM) mice[4].
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