2′-Hydroxychalcone

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells^[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp^[2]. In Vitro: 2′-Hydroxychalcone (10-90 μM; 12-72 h) suppresses cell viability in a dose-dependent manner, with IC₅₀ values of 37.74 μM and 34.26 μM for the two breast cancer cell lines MCF-7 and CMT-1211, respectively^[1].
2′-Hydroxychalcone (10-30 μM; 24 h) promotes autophagy vesicle accumulation in breast cancer cells^[1].
2′-Hydroxychalcone (30 μM; 24 h) induces autophagy-dependent apoptosis in breast cancer cells, and increases cleavage of caspase-3 and PARP^[1].
2′-Hydroxychalcone (10-30 μM; 24 h) significantly reduces the expression of p-IκB and p-NF-κBp65, and elevates the levels of p-ERK and p-JNK^[1].
2′-Hydroxychalcone (30 μM; 12-24 h) increased the intracellular ROS levels and triggered endoplasmic reticulum stress (ERS) of breast cancer cells^[1].
In Vivo: 2'-Hydroxychalcone (20-60 mg/kg; ip; every 2 days; 3 weeks) could exhibit an antitumor effect in vivo without causing significant toxicity to essential organs^[1].