Loxoribine
CAS No. : 121288-39-9
(Synonyms: 7-Allyl-8-oxoguanosine; RWJ 21757)
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $125 | In-stock |
| 50mg | $190 | In-stock |
| 100mg | $285 | In-stock |
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| Cat. No. : | HY-108472 |
| M.Wt: | 339.30 |
| Formula: | C13H17N5O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist[1][2][3].
IC50 & Target:TLR7[1]
In Vitro: Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability[2].
Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7[2].
loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1].
In Vivo: Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo[3].
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