PIM447
CAS No. : 1210608-43-7
(Synonyms: LGH447)
| Size | Price | Stock |
|---|---|---|
| 5mg | $340 | In-stock |
| 10mg | $550 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $2550 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19322 |
| M.Wt: | 440.46 |
| Formula: | C24H23F3N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis[1][2].
In Vitro: PIM447 (0.05-10 μM; 24-72 hours) shows antiproliferative effect on the multiple myeloma (MM) cells[2].
PIM447 (10 μM; 6-24 hours) induces apoptosis[2].
PIM447 (0.1-10 μM; 48 hours) increases the percentage of cells in the G0-G1 phase and decreases the proliferative phases (S and G2–M) of the cell cycle, in the two cell lines (MM1S and OPM-2 cells) at all doses[2].
In Vivo: PIM447 (100 mg/kg; p.o.; 5 times for a week) reduces tumor burden[2].
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